2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Glutathione Reductase (GR)

Glutathione Reductase (GR)

Glutathione Reductase

Glutathione reductase (GR) is a flavoenzyme whose main function is to catalyze the reduction of oxidized glutathione (GSSG) to reduced glutathione (GSH), playing a crucial role in the redox balance of cells. Glutathione reductase maintains the dynamic equilibrium between the two forms of glutathione within the cell, indirectly participates in antioxidant processes such as the elimination of reactive oxygen species in the cell, and protects cells from oxidative damage. In addition, it is also involved in the detoxification processes of organs such as the liver. Abnormal activity of glutathione reductase can lead to cellular redox imbalance and plays an important role in the occurrence and development of cardiovascular diseases, neurodegenerative diseases, hemolytic anemia, liver diseases, etc[1].

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-12542S
    Dantrolene-13C3
    		Inhibitor ≥99.0%
    Dantrolene-13C3 is the 13C3 labeled Dantrolene. Dantrolene (F368), a muscle relaxant, non-competitively inhibits human erythrocyte glutathione reductase. Ki and IC50 values are 111.6 μM and 52.3 μM, respectively. Dantrolene is a ryanodine receptor antagonist and Ca2+ signaling stabilizer. Dantrolene can be used for the research of muscle spasticity, malignant hyperthermia, Huntington's disease and other neuroleptic malignant syndrome.
    Dantrolene-<sup>13</sup>C<sub>3</sub>
  • HY-126849
    3-Morpholinosydnonimine
    		Inhibitor
    3-Morpholinosydnonimine (SIN-1) is a spontaneous ROS/RNS generator and peroxynitrite donor. 3-Morpholinosydnonimine induces oxidative stress-induced chondrocyte apoptosis and necrosis. 3-Morpholinosydnonimine inhibits the migration, proliferation and neointima formation of vascular smooth muscle cells by inhibiting the expression of annexin A2. In addition, low doses of 3-Morpholinosydnonimine shows protective effects on Zn2+ treated nerve cells.
    3-Morpholinosydnonimine
Cat. No. Product Name / Synonyms Application Reactivity